Ontology highlight
ABSTRACT:
SUBMITTER: Vaidyanathan PP
PROVIDER: S-EPMC2040082 | biostudies-literature | 2007 Nov
REPOSITORIES: biostudies-literature
Vaidyanathan Pavanapuresan P PP Deutscher Murray P MP Malhotra Arun A
RNA (New York, N.Y.) 20070913 11
Pseudouridine modifications in helix 69 (H69) of 23S ribosomal RNA are highly conserved among all organisms. H69 associates with helix 44 of 16S rRNA to form bridge B2a, which plays a vital role in bridging the two ribosomal subunits and stabilizing the ribosome. The three pseudouridines in H69 were shown earlier to play an important role in 50S subunit assembly and in its association with the 30S subunit. In Escherichia coli, these three modifications are made by the pseudouridine synthase, Rlu ...[more]