Ontology highlight
ABSTRACT:
SUBMITTER: Cui X
PROVIDER: S-EPMC2040436 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Cui Xiaoping X Meek Katheryn K
Proceedings of the National Academy of Sciences of the United States of America 20071015 43
Two major DNA repair pathways, nonhomologous end-joining (NHEJ) and homologous recombination (HR), repair double-stranded DNA breaks (DSBs) in all eukaryotes. Additionally, several alternative end-joining pathways (or subpathways) have been reported that characteristically use short-sequence homologies at the DNA ends to facilitate joining. How a cell chooses which DNA repair pathway to use (at any particular DSB) is a central and largely unanswered question. For one type of DSB, there is appare ...[more]