CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats.
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SUBMITTER: George O
PROVIDER: S-EPMC2040467 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
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CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats.
George Olivier O Ghozland Sandy S Azar Marc R MR Cottone Pietro P Zorrilla Eric P EP Parsons Loren H LH O'Dell Laura E LE Richardson Heather N HN Koob George F GF
Proceedings of the National Academy of Sciences of the United States of America 20071005 43
Nicotine, the main psychoactive ingredient of tobacco, induces negative emotional symptoms during abstinence that contribute to a profound craving for nicotine. However, the neurobiological mechanisms underlying how nicotine produces dependence remains poorly understood. We demonstrate one mechanism for both the anxiety-like symptoms of withdrawal and excessive nicotine intake observed after abstinence, through recruitment of the extrahypothalamic stress peptide corticotropin-releasing factor (C ...[more]
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