Ontology highlight
ABSTRACT:
SUBMITTER: Bodyak N
PROVIDER: S-EPMC2040477 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Bodyak Natalya N Ayus Juan Carlos JC Achinger Steven S Shivalingappa Venkatesha V Ke Qingen Q Chen Yee-Shiuan YS Rigor Debra L DL Stillman Isaac I Tamez Hector H Kroeger Paul E PE Wu-Wong Ruth R RR Karumanchi S Ananth SA Thadhani Ravi R Kang Peter M PM
Proceedings of the National Academy of Sciences of the United States of America 20071017 43
Observations in hemodialysis patients suggest a survival advantage associated with activated vitamin D therapy. Left ventricular (LV) structural and functional abnormalities are strongly linked with hemodialysis mortality. Here, we investigated whether paricalcitol (PC, 19-nor-1,25(OH)(2)D(2)), an activated vitamin D compound, attenuates the development of LV abnormalities in the Dahl salt-sensitive (DSS) rat and whether humans demonstrate comparable findings. Compared with DSS rats fed a high-s ...[more]