Ontology highlight
ABSTRACT:
SUBMITTER: Lerman G
PROVIDER: S-EPMC2040899 | biostudies-literature | 2007 Jul
REPOSITORIES: biostudies-literature
Lerman Gilad G Shakhnovich Boris E BE
Proceedings of the National Academy of Sciences of the United States of America 20070626 27
Although rigorous measures of similarity for sequence and structure are now well established, the problem of defining functional relationships has been particularly daunting. Here, we present several manifold embedding techniques to compute distances between Gene Ontology (GO) functional annotations and consequently estimate functional distances between protein domains. To evaluate accuracy, we correlate the functional distance to the well established measures of sequence, structural, and phylog ...[more]