Ontology highlight
ABSTRACT:
SUBMITTER: Jones KL
PROVIDER: S-EPMC2042191 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Jones Kristian L KL Mansell Ashley A Patella Shane S Scott Bernadette J BJ Hedger Mark P MP de Kretser David M DM Phillips David J DJ
Proceedings of the National Academy of Sciences of the United States of America 20071002 41
Activin A is a member of the transforming growth factor-beta superfamily, which we have identified as having a role in inflammatory responses. We show that circulating levels of activin increase rapidly after LPS-induced challenge through activation of Toll-like receptor 4 and the key adaptor protein, MyD88. Treatment with the activin-binding protein, follistatin, alters the profiles of TNF, IL-1beta, and IL-6 after LPS stimulation, indicating that activin modulates the release of several key pr ...[more]