The evolution of imprinting: chromosomal mapping of orthologues of mammalian imprinted domains in monotreme and marsupial mammals.
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ABSTRACT:
SUBMITTER: Edwards CA
PROVIDER: S-EPMC2042987 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Publications
The evolution of imprinting: chromosomal mapping of orthologues of mammalian imprinted domains in monotreme and marsupial mammals.
Edwards Carol A CA Rens Willem W Clarke Oliver O Mungall Andrew J AJ Hore Timothy T Graves Jennifer A Marshall JA Dunham Ian I Ferguson-Smith Anne C AC Ferguson-Smith Malcolm A MA
BMC evolutionary biology 20070906
<h4>Background</h4>The evolution of genomic imprinting, the parental-origin specific expression of genes, is the subject of much debate. There are several theories to account for how the mechanism evolved including the hypothesis that it was driven by the evolution of X-inactivation, or that it arose from an ancestrally imprinted chromosome.<h4>Results</h4>Here we demonstrate that mammalian orthologues of imprinted genes are dispersed amongst autosomes in both monotreme and marsupial karyotypes. ...[more]
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