Ontology highlight
ABSTRACT:
SUBMITTER: Daher W
PROVIDER: S-EPMC2043371 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Daher Wassim W Oria Gabrielle G Fauquenoy Sylvain S Cailliau Katia K Cailliau Katia K Browaeys Edith E Tomavo Stanislas S Khalife Jamal J
Eukaryotic cell 20070727 9
We have characterized the Toxoplasma gondii protein phosphatase type 1 (TgPP1) and a potential regulatory binding protein belonging to the leucine-rich repeat protein family, designated TgLRR1. TgLRR1 is capable of binding to TgPP1 to inhibit its activity and to override a G(2)/M cell cycle checkpoint in Xenopus oocytes. In the parasite, TgLRR1 mRNA and protein are both highly expressed in the rapidly replicating and virulent tachyzoites, while only low levels are detected in the slowly dividing ...[more]