Ontology highlight
ABSTRACT:
SUBMITTER: Lechler P
PROVIDER: S-EPMC2043510 | biostudies-literature | 2007 Nov
REPOSITORIES: biostudies-literature
Lechler Philipp P Wu Xiaoqing X Bernhardt Wanja W Campean Valentina V Gastiger Susanne S Hackenbeck Thomas T Klanke Bernd B Weidemann Alexander A Warnecke Christina C Amann Kerstin K Engehausen Dirk D Willam Carsten C Eckardt Kai-Uwe KU Rödel Franz F Wiesener Michael Sean MS
The American journal of pathology 20071101 5
The inhibitor of apoptosis protein survivin is of critical importance for regulation of cellular division and survival. Published data point to a restricted function of survivin in embryonic development and cancer; thus survivin has been broadly proposed as an ideal molecular target for specific anti-cancer therapy. In contrast to this paradigm, we report here broad expression of survivin in adult differentiated tissues, as demonstrated at the mRNA and protein levels. Focusing on the kidney, sur ...[more]