Ontology highlight
ABSTRACT:
SUBMITTER: Boudeau J
PROVIDER: S-EPMC204473 | biostudies-literature | 2003 Oct
REPOSITORIES: biostudies-literature
Boudeau Jérôme J Baas Annette F AF Deak Maria M Morrice Nick A NA Kieloch Agnieszka A Schutkowski Mike M Prescott Alan R AR Clevers Hans C HC Alessi Dario R DR
The EMBO journal 20031001 19
Mutations in the LKB1 protein kinase result in the inherited Peutz Jeghers cancer syndrome. LKB1 has been implicated in regulating cell proliferation and polarity although little is known about how this enzyme is regulated. We recently showed that LKB1 is activated through its interaction with STRADalpha, a catalytically deficient pseudokinase. Here we show that endogenous LKB1-STRADalpha complex is associated with a protein of unknown function, termed MO25alpha, through the interaction of MO25a ...[more]