Ontology highlight
ABSTRACT:
SUBMITTER: Liu Q
PROVIDER: S-EPMC2045076 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Liu Qiang Q Zerbinatti Celina V CV Zhang Juan J Hoe Hyang-Sook HS Wang Baiping B Cole Sarah L SL Herz Joachim J Muglia Louis L Bu Guojun G
Neuron 20071001 1
Mutations in the amyloid precursor protein (APP) cause early-onset Alzheimer's disease (AD), but the only genetic risk factor for late-onset AD is the varepsilon4 allele of apolipoprotein E (apoE), a major cholesterol carrier. Using Cre-lox conditional knockout mice, we demonstrate that lipoprotein receptor LRP1 expression regulates apoE and cholesterol levels within the CNS. We also found that deletion of APP and its homolog APLP2, or components of the gamma-secretase complex, significantly enh ...[more]