Ontology highlight
ABSTRACT:
SUBMITTER: Gajewski M
PROVIDER: S-EPMC2045077 | biostudies-literature | 2007 Aug
REPOSITORIES: biostudies-literature
Gajewski Mariusz M Seaver Ben B Esslinger C Sean CS
Bioorganic & medicinal chemistry letters 20070523 15
Novel triazole amino acids were synthesized as probes to investigate ligand-protein binding interactions of the neutral amino acid transporter SN1. The bonding hypothesis to be tested was that the side chains of endogenous substrates are acting as H-bond acceptors. Although limited inhibition of (3)H-L-glutamine uptake by SN1 expressing oocytes was observed, the synthetic compounds show a trend that suggests a hydrogen bond interaction just outside the endogenous ligand binding pocket. ...[more]