Ontology highlight
ABSTRACT:
SUBMITTER: Liu X
PROVIDER: S-EPMC2045126 | biostudies-literature | 2007 Nov
REPOSITORIES: biostudies-literature
Genes & development 20071101 21
The adenovirus (Ad) E1A (Ad-E1A) oncoprotein mediates cell transformation, in part, by displacing E2F transcription factors from the retinoblastoma protein (pRb) tumor suppressor. In this study we determined the crystal structure of the pRb pocket domain in complex with conserved region 1 (CR1) of Ad5-E1A. The structure and accompanying biochemical studies reveal that E1A-CR1 binds at the interface of the A and B cyclin folds of the pRb pocket domain, and that both E1A-CR1 and the E2F transactiv ...[more]