Induced prion protein controls immune-activated retroviruses in the mouse spleen.
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ABSTRACT:
SUBMITTER: Lotscher M
PROVIDER: S-EPMC2063463 | biostudies-literature | 2007
REPOSITORIES: biostudies-literature
Publications
Induced prion protein controls immune-activated retroviruses in the mouse spleen.
Lötscher Marius M Recher Mike M Lang Karl S KS Navarini Alexander A Hunziker Lukas L Santimaria Roger R Glatzel Markus M Schwarz Petra P Böni Jürg J Zinkernagel Rolf M RM
PloS one 20071107 11
The prion protein (PrP) is crucially involved in transmissible spongiform encephalopathies (TSE), but neither its exact role in disease nor its physiological function are known. Here we show for mice, using histological, immunochemical and PCR-based methods, that stimulation of innate resistance was followed by appearance of numerous endogenous retroviruses and ensuing PrP up-regulation in germinal centers of the spleen. Subsequently, the activated retroviruses disappeared in a PrP-dependent man ...[more]
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