Ontology highlight
ABSTRACT:
SUBMITTER: Kumar A
PROVIDER: S-EPMC2063476 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Kumar Amrita A Wu Huixia H Collier-Hyams Lauren S LS Hansen Jason M JM Li Tengguo T Yamoah Kosj K Pan Zhen-Qiang ZQ Jones Dean P DP Neish Andrew S AS
The EMBO journal 20071004 21
The resident prokaryotic microflora of the mammalian intestine influences diverse homeostatic functions of the gut, including regulation of cellular growth and immune responses; however, it is unknown how commensal prokaryotic organisms mechanistically influence eukaryotic signaling networks. We have shown that bacterial coculture with intestinal epithelial cells modulates ubiquitin-mediated degradation of important signaling intermediates, including beta-catenin and the NF-kappaB inhibitor Ikap ...[more]