Ontology highlight
ABSTRACT:
SUBMITTER: Gebhardt A
PROVIDER: S-EPMC2063541 | biostudies-literature | 2006 Jan
REPOSITORIES: biostudies-literature
Gebhardt Anneli A Frye Michaela M Herold Steffi S Benitah Salvador Aznar SA Braun Kristin K Samans Birgit B Watt Fiona M FM Elsässer Hans-Peter HP Eilers Martin M
The Journal of cell biology 20060101 1
Myc plays a key role in homeostasis of the skin. We show that Miz1, which mediates Myc repression of gene expression, is expressed in the epidermal basal layer. A large percentage of genes regulated by the Myc-Miz1 complex in keratinocytes encode proteins involved in cell adhesion, and some, including the alpha6 and beta1 integrins, are directly bound by Myc and Miz1 in vivo. Using a Myc mutant deficient in Miz1 binding (MycV394D), we show that Miz1 is required for the effects of Myc on keratino ...[more]