Ontology highlight
ABSTRACT:
SUBMITTER: Pal A
PROVIDER: S-EPMC2063679 | biostudies-literature | 2006 Feb
REPOSITORIES: biostudies-literature
Pal Arun A Severin Fedor F Lommer Barbara B Shevchenko Anna A Zerial Marino M
The Journal of cell biology 20060201 4
The molecular mechanisms underlying the targeting of Huntingtin (Htt) to endosomes and its multifaceted role in endocytosis are poorly understood. In this study, we have identified Htt-associated protein 40 (HAP40) as a novel effector of the small guanosine triphosphatase Rab5, a key regulator of endocytosis. HAP40 mediates the recruitment of Htt by Rab5 onto early endosomes. HAP40 overexpression caused a drastic reduction of early endosomal motility through their displacement from microtubules ...[more]