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Nomenclature for the human Arf family of GTP-binding proteins: ARF, ARL, and SAR proteins.

ABSTRACT: The Ras superfamily is comprised of at least four large families of regulatory guanosine triphosphate-binding proteins, including the Arfs. The Arf family includes three different groups of proteins: the Arfs, Arf-like (Arls), and SARs. Several Arf family members have been very highly conserved throughout eukaryotic evolution and have orthologues in evolutionally diverse species. The different means by which Arf family members have been identified have resulted in an inconsistent and confusing array of names. This confusion is further compounded by differences in nomenclature between different species. We propose a more consistent nomenclature for the human members of the Arf family that may also serve as a guide for nomenclature in other species.

SUBMITTER: Kahn RA

PROVIDER: S-EPMC2063696 | biostudies-literature | 2006 Feb

REPOSITORIES: biostudies-literature

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Nomenclature for the human Arf family of GTP-binding proteins: ARF, ARL, and SAR proteins.

Kahn Richard A RA Cherfils Jacqueline J Elias Marek M Lovering Ruth C RC Munro Sean S Schurmann Annette A

The Journal of cell biology 20060201 5

The Ras superfamily is comprised of at least four large families of regulatory guanosine triphosphate-binding proteins, including the Arfs. The Arf family includes three different groups of proteins: the Arfs, Arf-like (Arls), and SARs. Several Arf family members have been very highly conserved throughout eukaryotic evolution and have orthologues in evolutionally diverse species. The different means by which Arf family members have been identified have resulted in an inconsistent and confusing a ...[more]

PMID: 16505163

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