Ontology highlight
ABSTRACT:
SUBMITTER: Levy JR
PROVIDER: S-EPMC2063705 | biostudies-literature | 2006 Feb
REPOSITORIES: biostudies-literature
The Journal of cell biology 20060201 5
The microtubule motor cytoplasmic dynein and its activator dynactin drive vesicular transport and mitotic spindle organization. Dynactin is ubiquitously expressed in eukaryotes, but a G59S mutation in the p150Glued subunit of dynactin results in the specific degeneration of motor neurons. This mutation in the conserved cytoskeleton-associated protein, glycine-rich (CAP-Gly) domain lowers the affinity of p150Glued for microtubules and EB1. Cell lines from patients are morphologically normal but s ...[more]