Ontology highlight
ABSTRACT:
SUBMITTER: Hoffman LM
PROVIDER: S-EPMC2063708 | biostudies-literature | 2006 Feb
REPOSITORIES: biostudies-literature
Hoffman Laura M LM Jensen Christopher C CC Kloeker Susanne S Wang C-L Albert CL Yoshigi Masaaki M Beckerle Mary C MC
The Journal of cell biology 20060201 5
Focal adhesions are specialized regions of the cell surface where integrin receptors and associated proteins link the extracellular matrix to the actin cytoskeleton. To define the cellular role of the focal adhesion protein zyxin, we characterized the phenotype of fibroblasts in which the zyxin gene was deleted by homologous recombination. Zyxin-null fibroblasts display enhanced integrin-dependent adhesion and are more migratory than wild-type fibroblasts, displaying reduced dependence on extrac ...[more]