Ontology highlight
ABSTRACT:
SUBMITTER: Trajkovic K
PROVIDER: S-EPMC2063736 | biostudies-literature | 2006 Mar
REPOSITORIES: biostudies-literature
The Journal of cell biology 20060306 6
During vertebrate brain development, axons are enwrapped by myelin, an insulating membrane produced by oligodendrocytes. Neuron-derived signaling molecules are temporally and spatially required to coordinate oligodendrocyte differentiation. In this study, we show that neurons regulate myelin membrane trafficking in oligodendrocytes. In the absence of neurons, the major myelin membrane protein, the proteolipid protein (PLP), is internalized and stored in late endosomes/lysosomes (LEs/Ls) by a cho ...[more]