Ontology highlight
ABSTRACT:
SUBMITTER: Makhnevych T
PROVIDER: S-EPMC2064105 | biostudies-literature | 2007 Apr
REPOSITORIES: biostudies-literature
Makhnevych Taras T Ptak Christopher C Lusk C Patrick CP Aitchison John D JD Wozniak Richard W RW
The Journal of cell biology 20070402 1
In the yeast Saccharomyces cerevisiae, several components of the septin ring are sumoylated during anaphase and then abruptly desumoylated at cytokinesis. We show that septin sumoylation is controlled by the interactions of two enzymes of the sumoylation pathway, Siz1p and Ulp1p, with the nuclear transport machinery. The E3 ligase Siz1p is imported into the nucleus by the karyopherin Kap95p during interphase. In M phase, Siz1p is exported from the nucleus by the karyopherin Kap142p/Msn5p and sub ...[more]