Ontology highlight
ABSTRACT:
SUBMITTER: Gauthier NC
PROVIDER: S-EPMC2064141 | biostudies-literature | 2007 Apr
REPOSITORIES: biostudies-literature
Gauthier Nils C NC Monzo Pascale P Gonzalez Teresa T Doye Anne A Oldani Amanda A Gounon Pierre P Ricci Vittorio V Cormont Mireille M Boquet Patrice P
The Journal of cell biology 20070416 2
Glycosylphosphatidylinositol-anchored proteins (GPI-APs) are endocytosed by a clathrin- independent pathway into vesicles named GPI-AP-enriched early endosomal compartments (GEECs). We recently showed that the vacuolating toxin VacA secreted by Helicobacter pylori is endocytosed into the GEECs (Gauthier, N.C., P. Monzo, V. Kaddai, A. Doye, V. Ricci, and P. Boquet. 2005. Mol. Biol. Cell. 16:4852-4866). Unlike GPI-APs that are mostly recycled back to the plasma membrane, VacA reaches early endosom ...[more]