Ontology highlight
ABSTRACT:
SUBMITTER: Woll S
PROVIDER: S-EPMC2064280 | biostudies-literature | 2007 Jun
REPOSITORIES: biostudies-literature
Wöll Stefan S Windoffer Reinhard R Leube Rudolf E RE
The Journal of cell biology 20070529 5
Plasticity of the resilient keratin intermediate filament cytoskeleton is an important prerequisite for epithelial tissue homeostasis. Here, the contribution of stress-activated p38 MAPK to keratin network organization was examined in cultured cells. It was observed that phosphorylated p38 colocalized with keratin granules that were rapidly formed in response to orthovanadate. The same p38(p) recruitment was noted during mitosis, in various stress situations and in cells producing mutant keratin ...[more]