Ontology highlight
ABSTRACT:
SUBMITTER: Yang W
PROVIDER: S-EPMC2064387 | biostudies-literature | 2006 Sep
REPOSITORIES: biostudies-literature
Yang Weidong W Musser Siegfried M SM
The Journal of cell biology 20060918 7
Although many components and reaction steps necessary for bidirectional transport across the nuclear envelope (NE) have been characterized, the mechanism and control of cargo migration through nuclear pore complexes (NPCs) remain poorly understood. Single-molecule fluorescence microscopy was used to track the movement of cargos before, during, and after their interactions with NPCs. At low importin beta concentrations, about half of the signal-dependent cargos that interacted with an NPC were tr ...[more]