Ontology highlight
ABSTRACT:
SUBMITTER: Brandt DT
PROVIDER: S-EPMC2064439 | biostudies-literature | 2007 Jul
REPOSITORIES: biostudies-literature
Brandt Dominique T DT Marion Sabrina S Griffiths Gareth G Watanabe Takashi T Kaibuchi Kozo K Grosse Robert R
The Journal of cell biology 20070709 2
The Diaphanous-related formin Dia1 nucleates actin polymerization, thereby regulating cell shape and motility. Mechanisms that control the cellular location of Dia1 to spatially define actin polymerization are largely unknown. In this study, we identify the cytoskeletal scaffold protein IQGAP1 as a Dia1-binding protein that is necessary for its subcellular location. IQGAP1 interacts with Dia1 through a region within the Diaphanous inhibitory domain after the RhoA-mediated release of Dia1 autoinh ...[more]