Ontology highlight
ABSTRACT:
SUBMITTER: Bastide P
PROVIDER: S-EPMC2064470 | biostudies-literature | 2007 Aug
REPOSITORIES: biostudies-literature
Bastide Pauline P Darido Charbel C Pannequin Julie J Kist Ralf R Robine Sylvie S Marty-Double Christiane C Bibeau Frédéric F Scherer Gerd G Joubert Dominique D Hollande Frédéric F Blache Philippe P Jay Philippe P
The Journal of cell biology 20070801 4
The HMG-box transcription factor Sox9 is expressed in the intestinal epithelium, specifically, in stem/progenitor cells and in Paneth cells. Sox9 expression requires an active beta-catenin-Tcf complex, the transcriptional effector of the Wnt pathway. This pathway is critical for numerous aspects of the intestinal epithelium physiopathology, but processes that specify the cell response to such multipotential signals still remain to be identified. We inactivated the Sox9 gene in the intestinal epi ...[more]