Ontology highlight
ABSTRACT:
SUBMITTER: Takaesu G
PROVIDER: S-EPMC2064516 | biostudies-literature | 2006 Nov
REPOSITORIES: biostudies-literature
Takaesu Giichi G Kang Jong-Sun JS Bae Gyu-Un GU Yi Min-Jeong MJ Lee Clement M CM Reddy E Premkumar EP Krauss Robert S RS
The Journal of cell biology 20061030 3
The p38 mitogen-activated protein kinase (MAPK) pathway plays an important role in cell differentiation, but the signaling mechanisms by which it is activated during this process are largely unknown. Cdo is an immunoglobulin superfamily member that functions as a component of multiprotein cell surface complexes to promote myogenesis. In this study, we report that the Cdo intracellular region interacts with JLP, a scaffold protein for the p38alpha/beta MAPK pathway. Cdo, JLP, and p38alpha/beta fo ...[more]