Ontology highlight
ABSTRACT:
SUBMITTER: Cioce M
PROVIDER: S-EPMC2064518 | biostudies-literature | 2006 Nov
REPOSITORIES: biostudies-literature
Cioce Mario M Boulon Séverine S Matera A Gregory AG Lamond Angus I AI
The Journal of cell biology 20061101 3
The morphology and composition of subnuclear organelles, such as Cajal bodies (CBs), nucleoli, and other nuclear bodies, is dynamic and can change in response to a variety of cell stimuli, including stress. We show that UV-C irradiation disrupts CBs and alters the distribution of a specific subset of CB components. The effect of UV-C on CBs differs from previously reported effects of transcription inhibitors. We demonstrate that the mechanism underlying the response of CBs to UV-C is mediated, a ...[more]