EIF4E is a central node of an RNA regulon that governs cellular proliferation.
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ABSTRACT:
SUBMITTER: Culjkovic B
PROVIDER: S-EPMC2064519 | biostudies-literature | 2006 Nov
REPOSITORIES: biostudies-literature
Publications
eIF4E is a central node of an RNA regulon that governs cellular proliferation.
Culjkovic Biljana B Topisirovic Ivan I Skrabanek Lucy L Ruiz-Gutierrez Melisa M Borden Katherine L B KL
The Journal of cell biology 20061030 3
This study demonstrates that the eukaryotic translation initiation factor eIF4E is a critical node in an RNA regulon that impacts nearly every stage of cell cycle progression. Specifically, eIF4E coordinately promotes the messenger RNA (mRNA) export of several genes involved in the cell cycle. A common feature of these mRNAs is a structurally conserved, approximately 50-nucleotide element in the 3' untranslated region denoted as an eIF4E sensitivity element. This element is sufficient for locali ...[more]
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