Ontology highlight
ABSTRACT:
SUBMITTER: Pielage J
PROVIDER: S-EPMC2064525 | biostudies-literature | 2006 Nov
REPOSITORIES: biostudies-literature
Pielage Jan J Fetter Richard D RD Davis Graeme W GW
The Journal of cell biology 20061101 3
Synaptic connections are established with characteristic, cell type-specific size and spacing. In this study, we document a role for the postsynaptic Spectrin skeleton in this process. We use transgenic double-stranded RNA to selectively eliminate alpha-Spectrin, beta-Spectrin, or Ankyrin. In the absence of postsynaptic alpha- or beta-Spectrin, active zone size is increased and spacing is perturbed. In addition, subsynaptic muscle membranes are significantly altered. However, despite these chang ...[more]