Ontology highlight
ABSTRACT:
SUBMITTER: Griparic L
PROVIDER: S-EPMC2064541 | biostudies-literature | 2007 Aug
REPOSITORIES: biostudies-literature
Griparic Lorena L Kanazawa Takayuki T van der Bliek Alexander M AM
The Journal of cell biology 20070820 5
The dynamin-related protein Opa1 is localized to the mitochondrial intermembrane space, where it facilitates fusion between mitochondria. Apoptosis causes Opa1 release into the cytosol and causes mitochondria to fragment. Loss of mitochondrial membrane potential also causes mitochondrial fragmentation but not Opa1 release into the cytosol. Both conditions induce the proteolytic cleavage of Opa1, suggesting that mitochondrial fragmentation is triggered by Opa1 inactivation. The opposite effect wa ...[more]