Ontology highlight
ABSTRACT:
SUBMITTER: Brieher WM
PROVIDER: S-EPMC2064572 | biostudies-literature | 2006 Oct
REPOSITORIES: biostudies-literature
The Journal of cell biology 20061001 2
Actin filaments in cells depolymerize rapidly despite the presence of high concentrations of polymerizable G actin. Cofilin is recognized as a key regulator that promotes actin depolymerization. In this study, we show that although pure cofilin can disassemble Listeria monocytogenes actin comet tails, it cannot efficiently disassemble comet tails in the presence of polymerizable actin. Thymus extracts also rapidly disassemble comet tails, and this reaction is more efficient than pure cofilin whe ...[more]