Ontology highlight
ABSTRACT:
SUBMITTER: Schermer B
PROVIDER: S-EPMC2064591 | biostudies-literature | 2006 Nov
REPOSITORIES: biostudies-literature
The Journal of cell biology 20061113 4
Cilia are specialized organelles that play an important role in several biological processes, including mechanosensation, photoperception, and osmosignaling. Mutations in proteins localized to cilia have been implicated in a growing number of human diseases. In this study, we demonstrate that the von Hippel-Lindau (VHL) protein (pVHL) is a ciliary protein that controls ciliogenesis in kidney cells. Knockdown of pVHL impeded the formation of cilia in mouse inner medullary collecting duct 3 kidney ...[more]