Ontology highlight
ABSTRACT:
SUBMITTER: van den Boom V
PROVIDER: S-EPMC2064617 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
van den Boom Vincent V Kooistra Susanne M SM Boesjes Marije M Geverts Bart B Houtsmuller Adriaan B AB Monzen Koshiro K Komuro Issei I Essers Jeroen J Drenth-Diephuis Loes J LJ Eggen Bart J L BJ
The Journal of cell biology 20070904 6
Embryonic stem (ES) cells are able to grow indefinitely (self-renewal) and have the potential to differentiate into all adult cell types (pluripotency). The regulatory network that controls pluripotency is well characterized, whereas the molecular basis for the transition from self-renewal to the differentiation of ES cells is much less understood, although dynamic epigenetic gene silencing and chromatin compaction are clearly implicated. In this study, we report that UTF1 (undifferentiated embr ...[more]