Ontology highlight
ABSTRACT:
SUBMITTER: Wyatt L
PROVIDER: S-EPMC2064655 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Wyatt Leila L Wadham Carol C Crocker Lesley A LA Lardelli Michael M Khew-Goodall Yeesim Y
The Journal of cell biology 20070901 7
Epithelial-mesenchymal transition (EMT), crucial during embryogenesis for new tissue and organ formation, is also considered to be a prerequisite to cancer metastasis. We report here that the protein tyrosine phosphatase Pez is expressed transiently in discrete locations in developing brain, heart, pharyngeal arches, and somites in zebrafish embryos. We also find that Pez knock-down results in defects in these organs, indicating a crucial role in organogenesis. Overexpression of Pez in epithelia ...[more]