Ontology highlight
ABSTRACT:
SUBMITTER: Wozniak AL
PROVIDER: S-EPMC2064670 | biostudies-literature | 2006 Dec
REPOSITORIES: biostudies-literature
Wozniak Ann L AL Wang Xinmin X Stieren Emily S ES Scarbrough Shelby G SG Elferink Cornelis J CJ Boehning Darren D
The Journal of cell biology 20061127 5
Fas receptor is a member of the tumor necrosis factor-alpha family of death receptors that mediate physiologic apoptotic signaling. To investigate the molecular mechanisms regulating calcium mobilization during Fas-mediated apoptosis, we have analyzed the sequential steps leading to altered calcium homeostasis and cell death in response to activation of the Fas receptor. We show that Fas-mediated apoptosis requires endoplasmic reticulum-mediated calcium release in a mechanism dependent on phosph ...[more]