Ontology highlight
ABSTRACT:
SUBMITTER: Jansen JM
PROVIDER: S-EPMC2064675 | biostudies-literature | 2006 Dec
REPOSITORIES: biostudies-literature
Jansen Jaclyn M JM Barry Margaret F MF Yoo Charles K CK Weiss Eric L EL
The Journal of cell biology 20061201 5
The budding yeast regulation of Ace2 and morphogenesis (RAM) network integrates cell fate determination and morphogenesis. Its disruption impairs polarized growth and causes mislocalization of the transcription factor Ace2, resulting in failure of daughter cell-specific transcription required for cell separation. We find that phosphoregulation of the conserved AGC family kinase Cbk1 is critical for RAM network function. Intramolecular autophosphorylation of the enzyme's activation loop is critic ...[more]