Ontology highlight
ABSTRACT:
SUBMITTER: Chu T
PROVIDER: S-EPMC2064680 | biostudies-literature | 2006 Dec
REPOSITORIES: biostudies-literature
Chu Tony T Sun Ji J Saksena Suraj S Emr Scott D SD
The Journal of cell biology 20061201 5
The endosomal sorting complex required for transport (ESCRT) complexes play a critical role in receptor down-regulation and retroviral budding. Although the crystal structures of two ESCRT complexes have been determined, the molecular mechanisms underlying the assembly and regulation of the ESCRT machinery are still poorly understood. We identify a new component of the ESCRT-I complex, multivesicular body sorting factor of 12 kD (Mvb12), and demonstrate that Mvb12 binds to the coiled-coil domain ...[more]