The nuclear receptor hepatocyte nuclear factor 4alpha acts as a morphogen to induce the formation of microvilli.
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ABSTRACT:
SUBMITTER: Chiba H
PROVIDER: S-EPMC2064706 | biostudies-literature | 2006 Dec
REPOSITORIES: biostudies-literature
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The nuclear receptor hepatocyte nuclear factor 4alpha acts as a morphogen to induce the formation of microvilli.
Chiba Hideki H Sakai Naoyuki N Murata Masaki M Osanai Makoto M Ninomiya Takafumi T Kojima Takashi T Sawada Norimasa N
The Journal of cell biology 20061201 6
Microvilli are actin-based organelles found on apical plasma membranes that are involved in nutrient uptake and signal transduction. Numerous components, including ezrin/radixin/moesin (ERM) proteins, have been identified that link filamentous actins to transmembrane proteins, but the signals driving microvillus biogenesis are not known. In this study, we show that the conditional and/or ectopic expression of a nuclear receptor, hepatocyte nuclear factor 4alpha (HNF4alpha), triggers microvillus ...[more]
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