Ontology highlight
ABSTRACT:
SUBMITTER: Mirouse V
PROVIDER: S-EPMC2064817 | biostudies-literature | 2007 May
REPOSITORIES: biostudies-literature
The Journal of cell biology 20070430 3
LKB1 is mutated in both familial and spontaneous tumors, and acts as a master kinase that activates the PAR-1 polarity kinase and the adenosine 5'monophosphate-activated kinase (AMPK). This has led to the hypothesis that LKB1 acts as a tumor suppressor because it is required to maintain cell polarity and growth control through PAR-1 and AMPK, respectively. However, the genetic analysis of LKB1-AMPK signaling in vertebrates has been complicated by the existence of multiple redundant AMPK subunits ...[more]