The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts.
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ABSTRACT:
SUBMITTER: Li S
PROVIDER: S-EPMC2065883 | biostudies-literature | 2007 Nov
REPOSITORIES: biostudies-literature
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The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts.
Li Siguang S Sanna Serena S Maschio Andrea A Busonero Fabio F Usala Gianluca G Mulas Antonella A Lai Sandra S Dei Mariano M Orrù Marco M Albai Giuseppe G Bandinelli Stefania S Schlessinger David D Lakatta Edward E Scuteri Angelo A Najjar Samer S SS Guralnik Jack J Naitza Silvia S Crisponi Laura L Cao Antonio A Abecasis Gonçalo G Ferrucci Luigi L Uda Manuela M Chen Wei-Min WM Nagaraja Ramaiah R
PLoS genetics 20071101 11
High serum uric acid levels elevate pro-inflammatory-state gout crystal arthropathy and place individuals at high risk for cardiovascular morbidity and mortality. Genome-wide scans in the genetically isolated Sardinian population identified variants associated with serum uric acid levels as a quantitative trait. They mapped within GLUT9, a Chromosome 4 glucose transporter gene predominantly expressed in liver and kidney. SNP rs6855911 showed the strongest association (p = 1.84 x 10(-16)), along ...[more]
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