Ontology highlight
ABSTRACT:
SUBMITTER: Costet P
PROVIDER: S-EPMC207565 | biostudies-literature | 2003 Nov
REPOSITORIES: biostudies-literature
Costet Philippe P Lalanne Florent F Gerbod-Giannone Marie C MC Molina Jennifer R JR Fu Xuan X Lund Erik G EG Gudas Lorraine J LJ Tall Alan R AR
Molecular and cellular biology 20031101 21
ABCA1, the mutant molecule in Tangier Disease, mediates efflux of cellular cholesterol to apoA-I and is induced by liver X receptor (LXR)/retinoid X receptor (RXR) transcription factors. Retinoic acid receptor (RAR) activators (all-trans-retinoic acid [ATRA] and TTNPB) were found to increase ATP-binding cassette transporter 1 (ABCA1) mRNA and protein in macrophages. In cellular cotransfection assays, RARgamma/RXR activated the human ABCA1 promoter, via the same direct repeat 4 (DR4) promoter ele ...[more]