Ontology highlight
ABSTRACT:
SUBMITTER: Fraser C
PROVIDER: S-EPMC2077275 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Fraser Christophe C Hollingsworth T Déirdre TD Chapman Ruth R de Wolf Frank F Hanage William P WP
Proceedings of the National Academy of Sciences of the United States of America 20071022 44
The natural course of HIV-1 infection is characterized by a high degree of heterogeneity in viral load, not just within patients over time, but also between patients, especially during the asymptomatic stage of infection. Asymptomatic, or set-point, viral load has been shown to correlate with both decreased time to AIDS and increased infectiousness. The aim of this study is to characterize the epidemiological impact of heterogeneity in set-point viral load. By analyzing two cohorts of untreated ...[more]