Ontology highlight
ABSTRACT:
SUBMITTER: Lee HT
PROVIDER: S-EPMC2077833 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Lee Hyun-Tai HT Hennig Grant W GW Fleming Neal W NW Keef Kathleen D KD Spencer Nick J NJ Ward Sean M SM Sanders Kenton M KM Smith Terence K TK
Gastroenterology 20070620 3
<h4>Background & aims</h4>Like the heart, intestinal smooth muscles exhibit electrical rhythmicity, which originates in pacemaker cells surrounding the myenteric plexus, called interstitial cells of Cajal (ICC-MY). In large mammals, ICC also line septa (ICC-SEP) between circular muscle (CM) bundles, suggesting they might be necessary for activating muscle bundles. It is important to determine their functional significance, because a loss of ICC in humans is associated with disordered motility. O ...[more]