TNF polymorphisms modify endotoxin exposure-associated longitudinal lung function decline.

ABSTRACT:

Objectives

Endotoxin exposure induces airway inflammation, hyper-responsiveness and higher expression of tumour necrosis factor (TNF). This study was conducted to investigate whether TNF polymorphisms modify the effect of endotoxin exposure on chronic declines in lung function.

Methods

Associations between TNF and LTA polymorphisms, endotoxin exposure and lung function were analysed in 263 cotton workers and 230 silk workers as a reference group, who were prospectively followed for 20 years. Multiple linear regression models were used to assess the association, with adjustment for smoking and other covariates.

Results

Endotoxin exposure was associated with faster lung function decline among genotypes associated with higher TNF expression levels, with estimates of annu

SUBMITTER: Zhang H 

PROVIDER: S-EPMC2078509 | biostudies-literature | 2007 Jun

REPOSITORIES: biostudies-literature