Dataset Information

Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis.

ABSTRACT: We describe the genome sequence of the protist Trichomonas vaginalis, a sexually transmitted human pathogen. Repeats and transposable elements comprise about two-thirds of the approximately 160-megabase genome, reflecting a recent massive expansion of genetic material. This expansion, in conjunction with the shaping of metabolic pathways that likely transpired through lateral gene transfer from bacteria, and amplification of specific gene families implicated in pathogenesis and phagocytosis of host proteins may exemplify adaptations of the parasite during its transition to a urogenital environment. The genome sequence predicts previously unknown functions for the hydrogenosome, which support a common evolutionary origin of this unusual organelle with mitochondria.

SUBMITTER: Carlton JM

PROVIDER: S-EPMC2080659 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature

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Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis.

Carlton Jane M JM Hirt Robert P RP Silva Joana C JC Delcher Arthur L AL Schatz Michael M Zhao Qi Q Wortman Jennifer R JR Bidwell Shelby L SL Alsmark U Cecilia M UC Besteiro Sébastien S Sicheritz-Ponten Thomas T Noel Christophe J CJ Dacks Joel B JB Foster Peter G PG Simillion Cedric C Van de Peer Yves Y Miranda-Saavedra Diego D Barton Geoffrey J GJ Westrop Gareth D GD Müller Sylke S Dessi Daniele D Fiori Pier Luigi PL Ren Qinghu Q Paulsen Ian I Zhang Hanbang H Bastida-Corcuera Felix D FD Simoes-Barbosa Augusto A Brown Mark T MT Hayes Richard D RD Mukherjee Mandira M Okumura Cheryl Y CY Schneider Rachel R Smith Alias J AJ Vanacova Stepanka S Villalvazo Maria M Haas Brian J BJ Pertea Mihaela M Pertea Mihaela M Feldblyum Tamara V TV Utterback Terry R TR Shu Chung-Li CL Osoegawa Kazutoyo K de Jong Pieter J PJ Hrdy Ivan I Horvathova Lenka L Zubacova Zuzana Z Dolezal Pavel P Malik Shehre-Banoo SB Logsdon John M JM Henze Katrin K Gupta Arti A Wang Ching C CC Dunne Rebecca L RL Upcroft Jacqueline A JA Upcroft Peter P White Owen O Salzberg Steven L SL Tang Petrus P Chiu Cheng-Hsun CH Lee Ying-Shiung YS Embley T Martin TM Coombs Graham H GH Mottram Jeremy C JC Tachezy Jan J Fraser-Liggett Claire M CM Johnson Patricia J PJ

Science (New York, N.Y.) 20070101 5809

We describe the genome sequence of the protist Trichomonas vaginalis, a sexually transmitted human pathogen. Repeats and transposable elements comprise about two-thirds of the approximately 160-megabase genome, reflecting a recent massive expansion of genetic material. This expansion, in conjunction with the shaping of metabolic pathways that likely transpired through lateral gene transfer from bacteria, and amplification of specific gene families implicated in pathogenesis and phagocytosis of h ...[more]

PMID: 17218520

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Project description:BackgroundIn the UK, people of black Caribbean (BC) ethnicity continue to be disproportionately affected by bacterial sexually transmitted infections (STIs) and Trichomonas vaginalis (TV). We systematically reviewed evidence on the association between bacterial STIs/TV and ethnicity (BC compared to white/white British (WB)) accounting for other risk factors; and differences between these two ethnic groups in the prevalence of risk factors associated with these STIs, sexual healthcare seeking behaviours, and contextual factors influencing STI risk.MethodsStudies presenting relevant evidence for participants aged ≥14 years and living in the UK were eligible for inclusion. A pre-defined search strategy informed by the inclusion criteria was developed. Eleven electronic databases were searched from the start date to September-October 2016. Two researchers independently screened articles, extracted data using a standardised proforma and resolved discrepancies in discussion with a third researcher. Descriptive summaries of evidence are presented. Meta-analyses were not conducted due to variation in study designs. Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines were followed.ResultsOf 3815 abstracts identified, 15 articles reporting quantitative data were eligible and included in the review. No qualitative studies examining contextual drivers of STI risk among people of BC ethnicity were identified. Compared to the white/WB ethnic group, the greater STI/TV risk among BCs was partially explained by variations in socio-demographic factors, sexual behaviours, and recreational drug use. The prevalence of reporting early sexual debut (<16 years), concurrency, and multiple partners was higher among BC men compared to white/WB men; however, no such differences were observed for women. People of BC ethnicity were more likely to access sexual health services than those of white/WB ethnicity.ConclusionsFurther research is needed to explore other drivers of the sustained higher STI/TV prevalence among people of BC ethnicity. Developing holistic, tailored interventions that address STI risk and target people of BC ethnicity, especially men, could enhance STI prevention.

Dataset Information

Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis.

Publications

Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis.

Similar Datasets

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