Ontology highlight
ABSTRACT:
SUBMITTER: Fossati-Jimack L
PROVIDER: S-EPMC2080686 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Fossati-Jimack Liliane L Cortes-Hernandez Josefina J Norsworthy Peter J PJ Walport Mark J MJ Cook H Terence HT Botto Marina M
Molecular immunology 20070801 3
C1q-deficient mice have been shown to develop a lupus-like disease and to display an impaired clearance of apoptotic cells that are enriched in lupus autoantigens. However, the role of C1q in the regulation of autoreactive B cells remains debatable. To explore this we crossed MRL/Mp C1q-deficient mice with knock-in transgenic (Tg) mice expressing an anti-ssDNA antibody (VH3H9R and VH3H9R/VLkappa8R). Analysis of the VH3H9R mice showed that in the absence of C1q higher titres of Tg-derived IgM and ...[more]