Ontology highlight
ABSTRACT:
SUBMITTER: Anggono V
PROVIDER: S-EPMC2082060 | biostudies-literature | 2006 Jun
REPOSITORIES: biostudies-literature
Anggono Victor V Smillie Karen J KJ Graham Mark E ME Valova Valentina A VA Cousin Michael A MA Robinson Phillip J PJ
Nature neuroscience 20060430 6
Dynamin I is dephosphorylated at Ser-774 and Ser-778 during synaptic vesicle endocytosis (SVE) in nerve terminals. Phosphorylation was proposed to regulate the assembly of an endocytic protein complex with amphiphysin or endophilin. Instead, we found it recruits syndapin I for SVE and does not control amphiphysin or endophilin binding in rat synaptosomes. After depolarization, syndapin showed a calcineurin-mediated interaction with dynamin. A peptide mimicking the phosphorylation sites disrupted ...[more]