Ontology highlight
ABSTRACT:
SUBMITTER: Takagi F
PROVIDER: S-EPMC2084243 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Takagi Fumiko F Kikuchi Macoto M
Biophysical journal 20070817 11
We investigated the structural relaxation of myosin motor domain from the pre-power stroke state to the near-rigor state using molecular dynamics simulation of a coarse-grained protein model. To describe the spontaneous structural change, we propose a dual Gō-model-a variant of the Gō-like model that has two reference structures. The nucleotide dissociation process is also studied by introducing a coarse-grained nucleotide in the simulation. We found that the myosin structural relaxation toward ...[more]